![]() The adjusted odds ratio for an emergency room visit or inpatient admission for opioid overdose was 1.42 (1.33 to 1.51 P<0.001) for intermittent opioid users and 1.81 (1.67 to 1.96 P<0.001) chronic opioid users. ![]() ![]() Compared with opioid users who did not use benzodiazepines, concurrent use of both drugs was associated with an increased risk of an emergency room visit or inpatient admission for opioid overdose (adjusted odds ratio 2.14, 95% confidence interval 2.05 to 2.24 P<0.001) among all opioid users. This increase was driven mainly by increases among intermittent, as opposed to chronic, opioid users. RESULTS 9% of opioid users also used a benzodiazepine in 2001, increasing to 17% in 2013 (80% relative increase). MAIN OUTCOME MEASURES Annual percentage of opioid users with concurrent benzodiazepine use annual incidence of visits to emergency room and inpatient admissions for opioid overdose. INTERVENTIONS Concurrent benzodiazepine/opioid use, defined as an overlap of at least one day in the time periods covered by prescriptions for each drug. PARTICIPANTS 315 428 privately insured people aged 18-64 who were continuously enrolled in a health plan with medical and pharmacy benefits during the study period and who also filled at least one prescription for an opioid. SETTING Administrative health claims database. DESIGN Retrospective analysis of claims data, 2001-13. OBJECTIVES To identify trends in concurrent use of a benzodiazepine and an opioid and to identify the impact of these trends on admissions to hospital and emergency room visits for opioid overdose. ![]()
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